{"id":129513,"date":"2025-03-07T05:03:11","date_gmt":"2025-03-07T11:03:11","guid":{"rendered":"https:\/\/www.controleng.com\/?p=129513"},"modified":"2025-04-23T18:58:16","modified_gmt":"2025-04-23T23:58:16","slug":"startup-launched-for-crystallization-process-in-pharma-fine-chemicals","status":"publish","type":"post","link":"https:\/\/www.controleng.com\/startup-launched-for-crystallization-process-in-pharma-fine-chemicals\/","title":{"rendered":"Startup launched for crystallization process in pharma, fine chemicals"},"content":{"rendered":"\n

Crystallization Systems Technology Inc.<\/a>\u00a0(CrySyst), a technology-focused startup, has been launched to improve crystallization processes in the pharmaceutical and fine chemical industries. The move has implications for process monitoring, modeling and process control techniques.<\/p>\n\n\n\n

CrySyst\u2019s quality-by-control (QbC) framework focuses on crystallization monitoring, modeling, and control. It is based on research published in Crystal Growth & Design (April 15, 2020<\/a>; Oct. 5, 2021<\/a>) and Industrial & Engineering Chemistry Research (Sept. 22, 2022<\/a>).<\/p>\n\n\n\n

Zolt\u00e1n Nagy<\/a>, the Arvind Varma Professor of Chemical Engineering in Purdue University\u2019s Davidson School of Chemical Engineering<\/a>, and Botond Szil\u00e1gyi, a former postdoctoral research associate at Purdue and now an associate professor at Budapest University of Technology and Economics<\/a>, founded CrySyst.<\/p>\n\n\n\n

The Purdue Innovates Office of Technology Commercialization<\/a> has issued a license for CrySyst to commercialize copyright technologies CryMoCo and CrySIV.<\/p>\n\n\n\n

CrySiV and CryMoCo software solutions<\/h2>\n\n\n\n
\"\"
Zoltan Nagy<\/figcaption><\/figure>\n\n\n\n

Nagy said key challenges in model-based process development include determining necessary experiments, selecting appropriate model structures, and obtaining reliable model parameters.<\/p>\n\n\n\n

CrySiV and CryMoCo provide a structured method for crystallization process development.<\/p>\n\n\n\n

CryMoCo is instrument vendor-independent crystallization process monitoring and control software. It implements industry-standard communication protocols with typical process analytical technology tools and state-of-the-art process control methods, including direct nucleation control and supersaturation control approaches.<\/p>\n\n\n\n

CrySiV is a simulation tool designed for crystallization process modeling. It includes kinetic parameter regression, process simulation, and visualization.<\/p>\n\n\n\n

CryMoCo and CrySiV provide:<\/p>\n\n\n\n